One of the pioneer colleges established in September 2007 at the Osun State University Osogbo Main Campus. All programmes are fully accredited by the National Universities Commission (NUC). The college houses advanced laboratories, engineering workshops, and the Centre for Alternative Energies and Rural Technologies — a Centre of Excellence dedicated to sustainable innovation and applied technology research.

The college currently offers undergraduate programmes in Biochemistry, Biotechnology, Chemistry, Computer Science, Cyber Security, Geology, Industrial Chemistry, Information Technology, Microbiology, Physics with Electronics and Software Engineering. Engineering programmes include Agricultural Engineering, Chemical Engineering, Civil Engineering, Electrical/Electronics Engineering and Mechanical Engineering. Following strategic investments in infrastructure, the college continues to expand its research capacity and industry partnerships in science, engineering and technology innovation.

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